Publications

Our contributions to the scientific community

Oligodendroglia vulnerability in the human dorsal striatum in Parkinson's disease

Barba‑Reyes JM, Harder L, Marco Salas S, Jaisa‑Aad M, Muñoz‑Castro C, Garma LD, Rafati N, Nilsson M, Hyman BT, Serrano‑Pozo A, Muñoz‑Manchado AB

Acta Neuropathologica, 2025

DOI: 10.1007/s00401-025-02884-5

GPR37 processing in neurodegeneration: a potential marker for Parkinson's Disease progression rate

Argerich Bergadà J, Garma LD, López‑Cano M, Álvarez‑Montoya P, Gómez Acero L, Fernández Dueñas V, Muñoz‑Manchado AB, Aso Pérez E, Boxer A, Andrés‑Benito P, Svenningsson P, Ciruela Alférez F

npj Parkinson's Disease, 2024

DOI: 10.1038/s41531-024-00788-x

Interneuron diversity in the human dorsal striatum

Garma LD, Harder L, Barba‑Reyes JM, Marco Salas S, Díez‑Salguero M, Nilsson M, Serrano‑Pozo A, Hyman BT, Muñoz‑Manchado AB

Nature Communications, 2024

DOI: 10.1038/s41467-024-50414-w

Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration

Munguba H, Nikouei K, Hochgerner H, Oberst P, Kouznetsova A, Ryge J, Muñoz‑Manchado AB, Close J, Batista‑Brito R, Linnarsson S, Hjerling‑Leffler J

Neuron, 2023

DOI: 10.1016/j.neuron.2023.07.018

Deciphering the interneuron diversity in the human caudate nucleus and putamen using snRNA‑seq

Muñoz‑Manchado A, Garma L, Harder L, Barba Reyes JM, Díez Salguero M, Serrano Pozo A, Hyman B

IBRO Neuroscience Reports, 2023

DOI: 10.1016/j.ibneur.2023.08.403

Oligodendrocytes as a critical cell‑type in Parkinson's disease

Barba Reyes JM, Harder L, Díez Salguero M, Garma L, Serrano Pozo A, Hyman B, Muñoz‑Manchado A

IBRO Neuroscience Reports, 2023

DOI: 10.1016/j.ibneur.2023.08.692

Deciphering the role of the novel interneuron population PTHLH in the mouse striatum

Díez Salguero M, Harder L, Llorca‑Torralba M, Herr M, Barba Reyes JM, Berrocoso E, Hjerling‑Leffler J, Muñoz‑Manchado A

IBRO Neuroscience Reports, 2023

DOI: 10.1016/j.ibneur.2023.08.359

Protection and repair of the nigrostriatal pathway with stem‑cell‑derived carotid body glomus cell transplants in chronic MPTP parkinsonian model

Villadiego J, Muñoz‑Manchado AB, Sobrino V, Bonilla‑Henao V, Suárez‑Luna N, Ortega‑Sáenz P, Pardal R, López‑Barneo J, Toledo‑Aral JJ

International Journal of Molecular Sciences, 2023

DOI: 10.3390/ijms24065575

Postnatal Sox6 regulates synaptic function of cortical parvalbumin‑expressing neurons

Munguba H, Chattopadhyaya B, Nilsson S, Carriço JN, Memic F, Oberst P, Batista‑Brito R, Muñoz‑Manchado AB, Wegner M, Fishell G, Di Cristo G, Hjerling‑Leffler J

Journal of Neuroscience, 2021

DOI: 10.1523/JNEUROSCI.0021-21.2021

Intrinsic electrophysiological properties predict variability in morphology and connectivity among striatal Parvalbumin‑expressing Pthlh‑cells

Bengtsson Gonzales C, Hunt S, Muñoz‑Manchado AB, McBain CJ, Hjerling‑Leffler J

Scientific Reports, 2020

DOI: 10.1038/s41598-020-72588-1

Probabilistic cell typing enables fine mapping of closely related cell types in situ

Qian X, Harris KD, Hauling T, Nicoloutsopoulos D, Muñoz‑Manchado AB, Skene N, Hjerling‑Leffler J, Nilsson M

Nature Methods, 2020

DOI: 10.1038/s41592-019-0631-4

Genome‑wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz‑Manchado AB, Nagel M, Savage JE, Tiemeier H, White T, Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF, van der Sluis S, Polderman TJC, Smit AB, Hjerling‑Leffler J, Van Someren EJW, Posthuma D

Nature Genetics, 2019

DOI: 10.1038/s41588-018-0333-3

Biological annotation of genetic loci associated with intelligence in a meta‑analysis of 87,740 individuals

Coleman JRI, Bryois J, Gaspar HA, Jansen PR, Savage JE, Skene N, Plomin R, Muñoz‑Manchado AB, Linnarsson S, Crawford G, Hjerling‑Leffler J, Sullivan PF, Posthuma D, Breen G

Molecular Psychiatry, 2019

DOI: 10.1038/s41380-018-0040-6

Genome‑wide analysis of insomnia and sleep‑related traits in over 1 million individuals identifies novel genes and pathways

Jansen P, Watanabe K, Stringer S, Skene N, Bryois J, Muñoz‑Manchado AB, Tung J, Hinds D, Vacic V, Sullivan PF, Polderman T, Smit A, Hjerling‑Leffler J, Van Someren E, Posthuma D

European Neuropsychopharmacology, 2019

DOI: 10.1016/j.euroneuro.2018.08.072

Diversity of interneurons in the dorsal striatum revealed by single‑cell RNA sequencing and PatchSeq

Muñoz‑Manchado AB, Bengtsson Gonzales C, Zeisel A, Munguba H, Bekkouche B, Skene NG, Lönnerberg P, Ryge J, Harris KD, Linnarsson S, Hjerling‑Leffler J

Cell Reports, 2018

DOI: 10.1016/j.celrep.2018.07.053

Genome‑wide association meta‑analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Savage JE, Jansen PR, Stringer S, Watanabe K, Bryois J, de Leeuw CA, Nagel M, Awasthi S, Barr PB, Coleman JRI, et al.

Nature Genetics, 2018

DOI: 10.1038/s41588-018-0152-6

Meta‑analysis of genome‑wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

Nagel M, Jansen PR, Stringer S, Watanabe K, de Leeuw CA, Bryois J, Savage JE, Hammerschlag AR, Skene NG, Muñoz‑Manchado AB, White T, Tiemeier H, Linnarsson S, Hjerling‑Leffler J, Polderman TJC, Sullivan PF, van der Sluis S, Posthuma D

Nature Genetics, 2018

DOI: 10.1038/s41588-018-0151-7

Genetic identification of brain cell types underlying schizophrenia

Skene NG, Bryois J, Bakken TE, Breen G, Crowley JJ, Gaspar HA, Giusti‑Rodriguez P, Hodge RD, Miller JA, Muñoz‑Manchado AB, O'Donovan MC, Owen MJ, Pardiñas AF, Ryge J, Walters JTR, Linnarsson S, Lein ES, Working Group of the Psychiatric Genomics Consortium, Sullivan PF, Hjerling‑Leffler J

Nature Genetics, 2018

DOI: 10.1038/s41588-018-0129-5

Synaptic regulator α‑synuclein in dopaminergic fibers is essentially required for the maintenance of subependymal neural stem cells

Perez‑Villalba A, Sirerol‑Piquer MS, Belenguer G, Soriano‑Cantón R, Muñoz‑Manchado AB, Villadiego J, Alarcón‑Arís D, Soria FN, Dehay B, Bezard E, Vila M, Bortolozzi A, Toledo‑Aral JJ, Pérez‑Sánchez F, Fariñas I

Journal of Neuroscience, 2018

DOI: 10.1523/JNEUROSCI.2276-17.2017

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

Nguyen HT, Bryois J, Kim A, Dobbyn A, Huckins LM, Muñoz‑Manchado AB, Ruderfer DM, Genovese G, Fromer M, Xu X, Pinto D, Linnarsson S, Verhage M, Smit AB, Hjerling‑Leffler J, Buxbaum JD, Hultman C, Sklar P, Purcell SM, Lage K, He X, Sullivan PF, Stahl EA

Genome Medicine, 2017

DOI: 10.1186/s13073-017-0497-y

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Marques S, Zeisel A, Codeluppi S, Van Bruggen D, Falcão AM, Xiao L, Li H, Häring M, Hochgerner H, Romanov RA, Gyllborg D, Muñoz‑Manchado AB, La Manno G, Lönnerberg P, Floriddia EM, Rezayee F, Ernfors P, Arenas E, Hjerling‑Leffler J, Harkany T, Richardson WD, Linnarsson S, Castelo‑Branco G

Science, 2016

DOI: 10.1126/science.aaf6463

BCL11B/CTIP2 is highly expressed in GABAergic interneurons of the mouse somatosensory cortex

Nikouei K, Muñoz‑Manchado AB, Hjerling‑Leffler J

Journal of Chemical Neuroanatomy, 2016

DOI: 10.1016/j.jchemneu.2015.12.004

Chronic and progressive Parkinson's disease MPTP model in adult and aged mice

Muñoz‑Manchado AB, Villadiego J, Romo‑Madero S, Suárez‑Luna N, Bermejo‑Navas A, Rodríguez‑Gómez JA, Garrido‑Gil P, Labandeira‑García JL, Echevarría M, López‑Barneo J, Toledo‑Aral JJ

Journal of Neurochemistry, 2016

DOI: 10.1111/jnc.13409

Cell types in the mouse cortex and hippocampus revealed by single‑cell RNA‑seq

Zeisel A, Muñoz‑Manchado AB, Codeluppi S, Lönnerberg P, La Manno G, Juréus A, Marques S, Munguba H, He L, Betsholtz C, Rolny C, Castelo‑Branco G, Hjerling‑Leffler J, Linnarsson S

Science, 2015

DOI: 10.1126/science.aaa1934

Cellular properties and chemosensory responses of the human carotid body

Ortega‑Sáenz P, Pardal R, Levitsky K, Villadiego J, Muñoz‑Manchado AB, Durán R, Bonilla‑Henao V, Arias‑Mayenco I, Sobrino V, Ordoñez A, Oliver M, Toledo‑Aral JJ, López‑Barneo J

The Journal of Physiology, 2013

DOI: 10.1113/jphysiol.2013.263657

Neuroprotective and reparative effects of carotid body grafts in a chronic MPTP model of Parkinson's disease

Muñoz‑Manchado AB, Villadiego J, Suárez‑Luna N, Bermejo‑Navas A, Garrido‑Gil P, Labandeira‑García JL, Echevarría M, López‑Barneo J, Toledo‑Aral JJ

Neurobiology of Aging, 2013

DOI: 10.1016/j.neurobiolaging.2012.06.001

Cografting of carotid body cells improves the long‑term survival, fiber outgrowth and functional effects of grafted dopaminergic neurons

Rodriguez‑Pallares J, Joglar B, Muñoz‑Manchado AB, Villadiego J, Toledo‑Aral JJ, Labandeira‑Garcia JL

Regenerative Medicine, 2012

DOI: 10.2217/rme.12.22